General Overview
Digoxin increases the force of myocardial contraction and decreases heart rate. It has a narrow therapeutic index, meaning toxic levels are close to therapeutic levels.
Medicine Information
Digoxin
Digoxin
Prescription required
Cardiac Glycoside / Heart Failure
Medicine Safety Disclaimer
This information is for educational purposes only and should not be used for self-diagnosis or self-treatment. Do not start, stop, or change any medicine without consulting a qualified doctor or pharmacist. In case of overdose, severe allergic reaction, breathing difficulty, swelling of the face/lips, unconsciousness, or severe side effects, seek emergency medical help immediately.
Composition
Digoxin IP
Strength
0.25 mg (250 mcg)
Medicine Type
Tablet / Injection
Brand Names
Lanoxin
Dixin
Reported Uses
Used for chronic heart failure management and atrial fibrillation rate control.
General Characteristics
Improves heart pumping efficiency, reduces hospitalization rates in heart failure patients.
General Mechanism of Action
Inhibits sodium-potassium ATPase pump in myocardial cells, leading to increased intracellular calcium and stronger contraction.
Storage Guidelines
Store below 25°C in a dry place. Protect from light.
General Educational Notes
Ensure you maintain regular blood tests to check digoxin levels and potassium levels, as potassium levels dictate digoxin toxicity.
Frequently Asked Questions
What are the symptoms of Digoxin toxicity?
Common signs include loss of appetite, nausea, vomiting, confusion, weakness, and characteristic yellow-green visual halos.
Why does low potassium make Digoxin more toxic?
Digoxin binds to the same site as potassium on the ATPase pump. When potassium is low, more digoxin binds, enhancing its effects to toxic levels.