General Overview
Domperidone increases movements or contractions of the stomach and bowels. It acts on dopamine receptors in the gut and the chemoreceptor trigger zone.
Medicine Information
Domperidone
Domperidone
Prescription required
Antiemetic / Prokinetic
Medicine Safety Disclaimer
This information is for educational purposes only and should not be used for self-diagnosis or self-treatment. Do not start, stop, or change any medicine without consulting a qualified doctor or pharmacist. In case of overdose, severe allergic reaction, breathing difficulty, swelling of the face/lips, unconsciousness, or severe side effects, seek emergency medical help immediately.
Composition
Domperidone IP
Strength
10 mg
Medicine Type
Tablet / Suspension
Brand Names
Domstal
Motinorm
Vomistop
Reported Uses
Used for relief of nausea and vomiting, epigastric sense of fullness, and upper abdominal discomfort.
General Characteristics
Provides quick relief from vomiting. Often combined with proton pump inhibitors (PPIs) for acid reflux.
General Mechanism of Action
Peripheral dopamine receptor antagonist. Increases lower esophageal sphincter pressure and accelerates gastric emptying.
Storage Guidelines
Store below 30°C in a dry place. Protect from light.
General Educational Notes
Always take this medicine 15 to 30 minutes before eating. Taking it after meals can lead to delayed efficacy.
Frequently Asked Questions
Why is Domperidone taken before food?
Taking it before meals allows the drug to accelerate stomach emptying and prevent nausea triggered by food. Absorption is significantly reduced if taken after meals.
Does Domperidone affect prolactin levels?
Yes, Domperidone blocks dopamine (which normally inhibits prolactin], leading to increased prolactin levels. This can cause breast swelling or milk secretion in rare cases.