General Overview
Spironolactone prevents the body from absorbing too much salt and keeps potassium levels from getting too low. It is widely used in heart failure management, liver cirrhosis with ascites, and resistant hypertension.
Medicine Information
Spironolactone
Spironolactone
Prescription required
Cardiovascular / Diuretic
Medicine Safety Disclaimer
This information is for educational purposes only and should not be used for self-diagnosis or self-treatment. Do not start, stop, or change any medicine without consulting a qualified doctor or pharmacist. In case of overdose, severe allergic reaction, breathing difficulty, swelling of the face/lips, unconsciousness, or severe side effects, seek emergency medical help immediately.
Composition
Spironolactone IP
Strength
25 mg / 50 mg / 100 mg
Medicine Type
Tablet
Brand Names
Aldactone
Spilac
Reported Uses
Used in NYHA Class III-IV heart failure, primary hyperaldosteronism, liver cirrhosis with ascites, and essential hypertension.
General Characteristics
Improves survival in severe heart failure patients, reduces swelling and fluid retention in abdomen and legs.
General Mechanism of Action
Competitively inhibits aldosterone binding to receptors in the distal convoluted tubule and collecting duct, increasing sodium and water excretion while conserving potassium.
Storage Guidelines
Store below 30°C in a dry place. Keep container tightly closed.
General Educational Notes
To avoid waking up during the night to urinate, it is best to take this medicine in the morning, ideally before 12 PM.
Frequently Asked Questions
Does Spironolactone raise potassium levels?
Yes, Spironolactone is a potassium-sparing diuretic. It prevents your kidneys from excreting potassium, which can lead to high blood potassium levels.
Why do men experience breast enlargement on Spironolactone?
Spironolactone has mild anti-androgenic (anti-male hormone) effects, which can sometimes cause gynecomastia (breast enlargement in men) as a side effect.