General Overview
Clindamycin is effective against anaerobic bacteria and susceptible Gram-positive cocci. It carries a boxed warning for severe and sometimes fatal pseudomembranous colitis.
Medicine Information
Clindamycin
Clindamycin
Prescription required
Antibiotic
Medicine Safety Disclaimer
This information is for educational purposes only and should not be used for self-diagnosis or self-treatment. Do not start, stop, or change any medicine without consulting a qualified doctor or pharmacist. In case of overdose, severe allergic reaction, breathing difficulty, swelling of the face/lips, unconsciousness, or severe side effects, seek emergency medical help immediately.
Composition
Clindamycin Hydrochloride IP
Strength
150 mg / 300 mg / 600 mg
Medicine Type
Capsule / Injection / Topical Gel
Brand Names
Dalacin C
Clinka
Cleocin
Reported Uses
Used for dental/periodontal infections, bone and joint infections, pelvic inflammatory disease, and severe acne (topically).
General Characteristics
Excellent tissue penetration (especially bone and dental tissue], active against MRSA.
General Mechanism of Action
Inhibits bacterial protein synthesis by reversibly binding to the 50S ribosomal subunit, preventing peptide bond formation.
Storage Guidelines
Store at room temperature below 25°C. Do not refrigerate reconstituted liquid.
General Educational Notes
Take with a full glass of water and stay upright for at least 30 minutes after taking to prevent throat irritation or ulceration.
Frequently Asked Questions
Why does Clindamycin carry a black box warning?
Because it significantly disrupts the natural gut bacteria, allowing a bacterium called Clostridioides difficile to overgrow. This causes severe, potentially life-threatening colon inflammation (pseudomembranous colitis) characterized by intense diarrhea and abdominal cramps.
Can Clindamycin be used for dental infections?
Yes, Clindamycin is highly effective against anaerobic bacteria commonly found in tooth abscesses and jaw/gum infections, especially when penicillin is not an option.